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Gene ALK
Variant I1171N
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK I1171N lies within the protein kinase domain of the Alk protein (UniProt.org). I1171N results in increased ligand-independent Alk phosphorylation and activation of the Stat pathway in culture (PMID: 23239810, PMID: 21838707), activation in in vitro assays (PMID: 33674381, PMID: 25517749), is transforming in cell culture (PMID: 23239810, (PMID: 33674381, PMID: 25517749), and has been demonstrated to occur as a secondary resistance mutation in the context of ALK fusions (PMID: 27565911).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK act mut ALK I1171N

ALK mutant ALK I1171X ALK I1171N

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Transcript NM_004304.5
gDNA chr2:g.29222347A>T
cDNA c.3512T>A
Protein p.I1171N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29222347A>T c.3512T>A p.I1171N RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29222347A>T c.3512T>A p.I1171N RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222347A>T c.3512T>A p.I1171N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK I1171N gain of function ALK Inhibitor
EML4 - ALK ALK I1171N Brigatinib Ceritinib Lorlatinib
ALK rearrange ALK I1171N
EML4 - ALK ALK I1171N ALK G1269A
ALK rearrange ALK I1171N ALK L1198F
ALK rearrange ALK I1171N ALK D1203N
EML4 - ALK ALK I1171N ALK L1256F
EML4 - ALK ALK I1171N ALK F1174I
EML4 - ALK ALK I1171N ALK L1198H
EML4 - ALK ALK I1171N ALK F1174L
EML4 - ALK ALK I1171N ALK L1198F
EML4 - ALK ALK I1171N ALK L1196M
EML4 - ALK ALK I1171N ALK V1180L
EML4 - ALK ALK I1171N ALK L1196M ALK G1202R
EML4 - ALK ALK I1171N ALK D1203N
EML4 - ALK ALK E1129V ALK I1171N
EML4 - ALK ALK C1156Y ALK I1171N
ALK I1171N ALK pos
EML4 - ALK ALK I1171N ALK G1202R
EML4 - ALK ALK C1156Y ALK I1171N ALK L1198F