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|Gene Variant Descriptions||NOTCH1 P2438fs results in a change in the amino acid sequence of the Notch1 protein beginning at aa 2438 of 2555, likely resulting in premature truncation of the functional protein (UniProt.org). P2438fs is associated with increased copy number of the NOTCH1 gene in patient tumor samples (PMID: 25564152), but has not been biochemically characterized and therefore, its effect on Notch1 protein function is unknown (PubMed, Jun 2020).|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|