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|Protein Effect||no effect|
|Gene Variant Descriptions||TP53 dec exp indicates decreased expression of the Tp53 protein. However, the mechanism causing the decreased expression is unspecified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|TP53 dec exp||high grade glioma||sensitive||AZ32 + Radiotherapy||Preclinical - Cell culture||Actionable||In a preclinical study, shRNA knock-down of TP53 in malignant glioma cells enhanced sensitivity to the combination of AZ32 and radiation compared to TP53 wild-type cells in culture, and resulted in a greater decrease in cell survival and increased mitotic failure compared to either treatment treatment alone (PMID: 29769307).||29769307|
|Molecular Profile||Protein Effect||Treatment Approaches|
|TP53 dec exp||no effect|