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|Protein Effect||no effect|
|Gene Variant Descriptions||Wild-type CALR indicates that no mutation has been detected within the CALR gene.|
|Associated Drug Resistance|
|Molecular Profile||Protein Effect||Treatment Approaches|
|CALR wild-type||no effect|
|CALR wild-type JAK2 wild-type MPL wild-type|
|ASXL1 mut CALR wild-type|
|ASXL1 wild-type CALR wild-type|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|CALR wild-type JAK2 wild-type MPL wild-type||myelofibrosis||not applicable||N/A||Guideline||Prognostic||The presence of concurrent wild-type JAK2, MPL, and CALR in myelofibrosis patients is associated with inferior leukemia-free survival compared to patients with JAK2 and/or CALR mutations, and is associated with inferior overall survival when compared to patients with CALR mutations (NCCN.org).||detail...|
|ASXL1 mut CALR wild-type||myelofibrosis||not applicable||N/A||Guideline||Prognostic||The presence of an ASXL1 mutation combined with wild-type CALR is associated with shorter survival in patients with myelofibrosis (NCCN.org).||detail...|