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Gene CSF3R
Variant P467L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CSF3R P467L lies within the fibronectin type-III domain 4 of the Csf3r protein (UniProt.org). P467L has not been characterized in the scientific literature and therefore, its effect on Csf3r protein function is unknown (PubMed, Jul 2020).
Associated Drug Resistance

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Transcript NM_000760
gDNA chr1:g.36469726G>A
cDNA c.1400C>T
Protein p.P467L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011540748 chr1:g.36469726G>A c.1400C>T p.P467L RefSeq GRCh38/hg38
XM_011540749 chr1:g.36469726G>A c.1400C>T p.P467L RefSeq GRCh38/hg38
XM_005270493 chr1:g.36469726G>A c.1400C>T p.P467L RefSeq GRCh38/hg38
NM_156039 chr1:g.36469726G>A c.1400C>T p.P467L RefSeq GRCh38/hg38
NM_172313 chr1:g.36469726G>A c.1400C>T p.P467L RefSeq GRCh38/hg38
NM_000760 chr1:g.36469726G>A c.1400C>T p.P467L RefSeq GRCh38/hg38
XM_017000370 chr1:g.36469726G>A c.1400C>T p.P467L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CSF3R mutant bone marrow cancer not applicable N/A Clinical Study Emerging In clinical studies, high frequency of CSF3R mutations was identified in patients with chronic neutrophilic leukemia (PMID: 23656643, PMID: 24081659), suggesting that this may serve as a future diagnostic biomarker (PMID: 24441292). 24081659 23656643 24441292
Molecular Profile Protein Effect Treatment Approaches
CSF3R P467L unknown