Gene Variant Detail

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Gene TP53
Variant P177T
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 P177T lies within the DNA binding domain of the Tp53 protein (UniProt.org). P177T results in a loss of Tp53 function as indicated by inability to bind DNA or activate transcription in cell culture (PMID: 21643018).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 P177T

TP53 mutant TP53 inact mut TP53 P177T

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Transcript NM_000546.5
gDNA chr17:g.7675083G>T
cDNA c.529C>A
Protein p.P177T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114 chr17:g.7675083G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126116 chr17:g.7673603G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126117.1 chr17:g.7673603G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675083G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675083G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675083G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_000546 chr17:g.7675083G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126115.1 chr17:g.7673603G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126115 chr17:g.7673603G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126117 chr17:g.7673603G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675083G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126116.1 chr17:g.7673603G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675083G>T c.529C>A p.P177T RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675083G>T c.529C>A p.P177T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 P177T osteosarcoma resistant Nutlin-3a Preclinical Actionable In a preclinical study, TP53 P177T resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018). 21643018