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Gene DNMT3A
Variant V649M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A V649M lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). V649M has not been characterized in the scientific literature and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A V649M

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Transcript NM_022552.5
gDNA chr2:g.25241699C>T
cDNA c.1945G>A
Protein p.V649M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532667.3 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
XM_047443598.1 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
XM_011532663 chr2:g.25240703C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_047443594.1 chr2:g.25236989C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_005264175 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_017003526 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_011532664 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_011532667.4 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_047443597.1 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
XM_005264177.4 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_047443596.1 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
XM_011532663.2 chr2:g.25240703C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_011532667 chr2:g.25234402_25234404delGACinsCAT c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_005264177 chr2:g.25234402_25234404delGACinsCAT c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
NM_175629 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
NM_022552 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_017003527.2 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25241699C>T c.1945G>A p.V649M RefSeq GRCh38/hg38
XM_017003527 chr2:g.25234402_25234404delGACinsCAT c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
XM_017003527.1 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38
NM_001375819.1 chr2:g.25234402_25234404delGTCinsATG c.1945_1947delGTCinsATG p.V649M RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References