Gene Variant Detail

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Gene MPL
Variant T487V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MPL T487V lies within the extracellular domain of the Mpl protein (UniProt.org). T487V is not transforming in cell culture (PMID: 18755984), but has not been fully biochemically characterized and therefore, its effect on Mpl protein function is unknown (PubMed, Mar 2020).
Associated Drug Resistance

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Transcript NM_005373
gDNA chr1:g.43348993_43348994delACinsGT
cDNA c.1459_1460delACinsGT
Protein p.T487V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005373 chr1:g.43348993_43348994delACinsGT c.1459_1460delACinsGT p.T487V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
MPL T487V unknown