Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene ALK
Variant G1202R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK G1202R lies within the protein kinase domain of the Alk protein (UniProt.org). G1202R demonstrates increased colony formation, decreased Cdh1 expression, increased migration and invasion, increased expression of metastatic factors Cdh2, Vim, Mmp2, Mmp9, and Slug in cell culture in the context of EML4-ALK (PMID: 35085771), and drug resistance in the context of ALK fusions (PMID: 22277784, PMID: 24736079, PMID: 35085771), but has not been individually characterized and therefore, its effect on Alk protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK G1202X ALK G1202R

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_004304.5
gDNA chr2:g.29220747C>T
cDNA c.3604G>A
Protein p.G1202R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29220747C>T c.3604G>A p.G1202R RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220747C>T c.3604G>A p.G1202R RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220747C>T c.3604G>A p.G1202R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK G1202R unknown
EML4 - ALK ALK G1202R Brigatinib Lorlatinib
ALK fusion ALK G1202R
EML4 - ALK ALK L1198F ALK G1202R Crizotinib
ALK rearrange ALK G1202R
EML4 - ALK ALK F1174V ALK G1202R
EML4 - ALK ALK L1196M ALK G1202R
ALK rearrange ALK G1202R ALK G1269A
ALK rearrange ALK L1196M ALK G1202R
ALK rearrange ALK G1202R ALK L1204V ALK G1269A
ALK rearrange ALK V1180L ALK L1196M ALK G1202R
ALK fusion ALK G1202R KIT amp
ALK rearrange ALK F1174L ALK G1202R
ALK rearrange ALK F1174C ALK G1202R
ALK rearrange ALK T1151M ALK G1202R
ALK G1202R ALK pos
EML4 - ALK ALK E1154K ALK G1202R ALK I1268V
EML4 - ALK ALK T1151M ALK C1156Y ALK F1174L ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK F1174L ALK G1202R
EML4 - ALK ALK C1156Y ALK G1202R
EML4 - ALK ALK G1202R ALK G1269A
EML4 - ALK ALK G1202R ALK L1204V ALK G1269A
EML4 - ALK ALK L1198F ALK G1202R ALK G1269A
EML4 - ALK ALK V1180L ALK G1202R
EML4 - ALK ALK C1156Y ALK L1196M ALK G1202R
ALK L1198F ALK G1202R
EML4 - ALK ALK I1171N ALK L1196M ALK G1202R
EML4 - ALK ALK G1202R ALK S1206F
EML4 - ALK ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK T1151K ALK G1202R ALK S1206F
ALK fusion ALK L1196M ALK G1202R
ALK fusion ALK G1202R ALK L1204V ALK G1269A
ALK fusion ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK L1196M ALK G1202R ALK D1203N
EML4 - ALK ALK E1129V ALK G1202R
EML4 - ALK ALK F1174C ALK G1202R
EML4 - ALK ALK F1174I ALK G1202R
EML4 - ALK ALK T1151M ALK G1202R
EML4 - ALK ALK I1171N ALK G1202R
ALK G1202R ALK R1275Q
ALK G1202R ALK R1275Q BRAF V600E
ALK F1174L ALK G1202R ALK D1203N ALK amp
ALK F1174L ALK G1202R
ALK G1202R ALK D1276_R1279delinsE