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Gene | ATM |
Variant | del |
Impact List | deletion |
Protein Effect | loss of function |
Gene Variant Descriptions | ATM del indicates a deletion of the ATM gene. |
Associated Drug Resistance | |
Category Variants Paths |
ATM mutant ATM inact mut ATM del |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM del ATR dec exp | Advanced Solid Tumor | decreased response | PJ34 | Preclinical - Cell culture | Actionable | In a preclinical study, ATM-null transformed cells with decreased Atr expression demonstrated decreased sensitivity to PJ34 in culture (PMID: 21840268). | 21840268 |