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Gene | NOTCH1 |
Variant | rearrange |
Impact List | unknown |
Protein Effect | unknown |
Gene Variant Descriptions | NOTCH1 rearrange indicates an unspecified rearrangement of the NOTCH1 gene. |
Associated Drug Resistance |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NOTCH1 rearrange | triple-receptor negative breast cancer | no benefit | MRK-003 + SCH772984 | Preclinical | Actionable | In a preclinical study, SCH772984 did not potentiate the growth inhibition effect of MRK-003 in triple receptor-negative breast cancer cells harboring NOTCH1 rearrangement in culture (PMID: 25104330). | 25104330 |
NOTCH1 rearrange | triple-receptor negative breast cancer | sensitive | MRK-003 | Preclinical | Actionable | In a preclinical study, MRK-003 inhibited growth of triple receptor-negative breast cancer cells harboring NOTCH1 rearrangement in culture and reduced tumor growth in xenograft models (PMID: 25104330). | 25104330 |
NOTCH1 rearrange | triple-receptor negative breast cancer | sensitive | MRK-003 + Paclitaxel | Preclinical | Actionable | In a preclinical study, MRK-003 and Taxol (paclitaxel) worked synergistically to inhibit tumor growth in triple receptor-negative breast cancer xenograft models harboring NOTCH1 rearrangement, resulting in tumor regression (PMID: 25104330). | 25104330 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
NOTCH1 rearrange | unknown |