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|Gene Variant Descriptions||CBL Q249E lies within the Cbl-PTB domain of the Cbl protein (UniProt.org). Q249E is conflicting, as it results in increased Cbl activity, as demonstrated by increased ubiquitination of Egfr compared to wild-type Cbl in cultured cells in one study (PMID: 26676746), but ubiquinates Egfr similar to wild-type in another study (PMID: 20126411), and results in increased viability (PMID: 20126411), and Met expression in cell lines (PMID: 28835699), and therefore, its effect on Cbl protein function is unknown.|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|