Gene Variant Detail

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Gene TP53
Variant H193Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 H193Q lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). H193Q has been identified in the scientific literature (PMID: 23200980), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 H193Q

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Transcript NM_000546.6
gDNA chr17:g.7674952A>T
cDNA c.579T>A
Protein p.H193Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_000546 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674952A>T c.579T>A p.H193Q RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References