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Gene FLT3
Variant M837G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 M837G lies within the protein kinase domain of the Flt3 protein (UniProt.org). M837G has been demonstrated to confer drug resistance when in the context of FLT3 internal tandem duplication (FLT3-ITD) compound mutations co-occurring in tandem with S838R and D839H (PMID: 25847190), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Oct 2022).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 M837G

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Transcript NM_004119.2
gDNA chr13:g.28018498_28018499delATinsGG
cDNA c.2509_2510delATinsGG
Protein p.M837G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018498_28018499delATinsGG c.2509_2510delATinsGG p.M837G RefSeq GRCh38/hg38
NM_004119 chr13:g.28018498_28018499delATinsCC c.2509_2510delATinsGG p.M837G RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 M837G FLT3 S838R FLT3 D839H leukemia predicted - resistant Pexidartinib Case Reports/Case Series Actionable In a clinical case study, a leukemia patient with FLT3-ITD positive leukemia initially responded to Pexidartinib (PLX3397), but experienced relapse after emergence of a compound FLT3 M837G/S838R/D839H mutation on the FLT3-ITD allele (PMID: 25847190). 25847190