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Gene FLT3
Variant S652G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 S652G lies within the protein kinase domain of the Flt3 protein (UniProt.org). S652G has been identified in sequencing studies (PMID: 25847190), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Sep 2022).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon16 FLT3 S652G

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Transcript NM_004119.2
gDNA chr13:g.28028277T>C
cDNA c.1954A>G
Protein p.S652G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28028277T>C c.1954A>G p.S652G RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28028277T>C c.1954A>G p.S652G RefSeq GRCh38/hg38
XM_017020486.1 chr13:g.28027125T>C c.1954A>G p.S652G RefSeq GRCh38/hg38
XM_017020486 chr13:g.28027125T>C c.1954A>G p.S652G RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 S652G leukemia predicted - resistant Pexidartinib Case Reports/Case Series Actionable In a clinical case study, a patient with FLT3-ITD positive leukemia initially responded to Pexidartinib (PLX3397), but experienced relapse after emergence of a FLT3 S652G mutation on the same allele as FLT3-ITD (PMID: 25847190). 25847190