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|Protein Effect||no effect|
|Gene Variant Descriptions||KDR (VEGFR2) over exp indicates an over expression of the Kdr (Vegfr2) protein and/or mRNA. However, the mechanism causing the over expression is unspecified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KDR over exp||breast cancer||predicted - resistant||Sunitinib||Preclinical||Actionable||In a preclinical study, upregulation of Kdr (Vegfr2) was identified in tumors acquired resistance to Sutent (sunitinib) in allograft models of breast cancer (PMID: 28011623).||28011623|
|Molecular Profile||Protein Effect||Treatment Approaches|
|KDR over exp||no effect|