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Gene ALK
Variant T1151M
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ALK T1151M lies within the protein kinase domain of the Alk protein (UniProt.org). T1151M is not transforming (PMID: 18923525, PMID: 33674381, PMID: 25517749) and does not induce Alk phosphorylation in culture (PMID: 18923525), but is activating in in vitro assays (PMID: 33674381, PMID: 25517749), and has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK fusions (PMID: 28676215, PMID: 27009859), and therefore, is predicted to lead to a gain of Alk protein function.
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK act mut ALK T1151M

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Transcript NM_004304.5
gDNA chr2:g.29222407G>A
cDNA c.3452C>T
Protein p.T1151M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29222407G>A c.3452C>T p.T1151M RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222407G>A c.3452C>T p.T1151M RefSeq GRCh38/hg38
NM_004304 chr2:g.29222407G>A c.3452C>T p.T1151M RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK T1151M Advanced Solid Tumor predicted - sensitive TPX-0131 Preclinical - Biochemical Actionable In a preclinical study, TPX-0131 inhibited kinase activity of ALK T1151M in an in vitro assay (PMID: 34158340). 34158340