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|Gene Variant Descriptions||ALK E1210K lies within the protein kinase domain of the Alk protein (UniProt.org). E1210K has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK fusions (PMID: 29650534, PMID: 25914136, PMID: 27432227), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Oct 2022).|
|Associated Drug Resistance||Y|
|Category Variants Paths||
ALK mutant ALK E1210K
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Protein Effect||Treatment Approaches|
|EML4 - ALK ALK E1210K||Alectinib Brigatinib Ceritinib Lorlatinib|
|EML4 - ALK ALK D1203N ALK E1210K||Lorlatinib|
|ALK rearrange ALK D1203N ALK E1210K ALK G1269A|
|EML4 - ALK ALK S1206C ALK E1210K|
|ALK rearrange ALK E1210K|
|ALK S1206C ALK E1210K|
|ALK D1203N ALK E1210K|
|EML4 - ALK ALK F1174C ALK E1210K|
|ALK fusion ALK D1203N ALK E1210K ALK G1269A|