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|Gene Variant Descriptions||ALK L1152R lies within the protein kinase domain of the Alk protein (UniProt.org). L1152R has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK fusions (PMID: 35123209, PMID: 36064579, PMID: 27091190), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Oct 2022).|
|Associated Drug Resistance||Y|
|Category Variants Paths||
ALK mutant ALK L1152R
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|