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Gene ALK
Variant C1156Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK C1156Y lies within the protein kinase domain of the Alk protein (UniProt.org). C1156Y has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK fusions (PMID: 21613408, PMID: 20979473, PMID: 27490033, PMID: 27045755), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK C1156Y

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Transcript NM_004304.5
gDNA chr2:g.29222392C>T
cDNA c.3467G>A
Protein p.C1156Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29222392C>T c.3467G>A p.C1156Y RefSeq GRCh38/hg38
NM_004304 chr2:g.29222392C>T c.3467G>A p.C1156Y RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222392C>T c.3467G>A p.C1156Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK C1156Y unknown
EML4 - ALK ALK C1156Y Alectinib Brigatinib Ensartinib Lorlatinib
ALK fusion ALK C1156Y
ALK rearrange ALK C1156Y
ALK rearrange ALK C1156Y ALK L1198F
EML4 - ALK ALK C1156Y ALK L1198F Crizotinib
EML4 - ALK ALK C1156Y ALK L1196M
EML4 - ALK ALK C1156Y ALK I1171T
EML4 - ALK ALK C1156Y ALK F1174C
EML4 - ALK ALK C1156Y ALK F1174I
EML4 - ALK ALK C1156Y ALK F1174V
EML4 - ALK ALK C1156Y ALK D1203N
EML4 - ALK ALK C1156Y ALK L1256F
EML4 - ALK ALK C1156Y ALK G1269A
ALK C1156Y ALK pos
EML4 - ALK ALK T1151M ALK C1156Y ALK F1174L ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK C1156Y ALK G1202R
EML4 - ALK ALK C1156Y ALK L1196M ALK G1202R
ALK C1156Y ALK L1198F
ALK fusion ALK C1156Y ALK L1198F
EML4 - ALK ALK C1156Y ALK I1171N
EML4 - ALK ALK C1156Y ALK I1171N ALK L1198F
EML4 - ALK ALK C1156Y ALK I1171T ALK L1198F