Gene Variant Detail

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Gene FGFR1
Variant A263V
Impact List missense
Protein Effect no effect
Gene Variant Descriptions FGFR1 A263V lies within the Ig-like C2-type domain 3 of the Fgfr1 protein (UniProt.org). A263V demonstrates phosphorylation levels similar to wild-type Fgfr1 and is not transforming in culture (PMID: 26826182) and therefore, has no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 A263V

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Transcript NM_023110.3
gDNA chr8:g.38424657G>A
cDNA c.788C>T
Protein p.A263V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017013228 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716313 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_001354370.1 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_017013221 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_001354368.1 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_047421574.1 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_001354370.2 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716314.3 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_017013222 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_023106.2 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_001174063 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_023110 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716303 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_023106 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716314.2 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_001354368.2 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
NM_023106.3 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716314 chr8:g.38421817G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716304 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38424657G>A c.788C>T p.A263V RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References