Gene Variant Detail

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Gene DDR2
Variant H246R
Impact List missense
Protein Effect no effect
Gene Variant Descriptions DDR2 H246R lies within the extracellular domain of the Ddr2 protein (UniProt.org). H246R demonstrates phosphorylation levels similar to wild-type Ddr2 and is not transforming in culture (PMID: 26826182).
Associated Drug Resistance

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Transcript NM_001014796
gDNA chr1:g.162759861A>G
cDNA c.737A>G
Protein p.H246R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006711344 chr1:g.162759861A>G c.737A>G p.H246R RefSeq GRCh38/hg38
XM_011509587 chr1:g.162759861A>G c.737A>G p.H246R RefSeq GRCh38/hg38
XM_011509588 chr1:g.162759861A>G c.737A>G p.H246R RefSeq GRCh38/hg38
NM_001014796 chr1:g.162759861A>G c.737A>G p.H246R RefSeq GRCh38/hg38
NM_006182 chr1:g.162759861A>G c.737A>G p.H246R RefSeq GRCh38/hg38
XM_011509586 chr1:g.162759861A>G c.737A>G p.H246R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
DDR2 mutant lung squamous cell carcinoma sensitive Dasatinib Preclinical Actionable In a preclinical study, lung squamous cell cancer cells harboring DDR2 mutations demonstrated sensitivity to Sprycel (dasatinib) in culture (PMID: 22328973). 22328973
Molecular Profile Protein Effect Treatment Approaches
DDR2 H246R no effect