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|Protein Effect||no effect|
|Gene Variant Descriptions||RET over exp indicates an over expression of the Ret protein. However, the mechanism causing the over expression is unspecified.|
|Associated Drug Resistance|
|Molecular Profile||Protein Effect||Treatment Approaches|
|RET over exp||no effect|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RET over exp||breast cancer||sensitive||Y078-DM1||Preclinical - Cell line xenograft||Actionable||In a preclinical study, Y078-DM1 induced cytotoxicity in a human breast cancer cell line with high levels of RET expression in culture and inhibited tumor growth in xenograft models (PMID: 26240273).||26240273|