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Gene TP53
Variant G334R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 G334R lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). The functional effect of G334R is conflicting as it demonstrates Tp53 transactivation activity in a luciferase assay and suppresses colony formation in cell culture (PMID: 25584008), however, results in similar induction of MDM2 and p21, but decreased transactivation of a subset of Tp53 target genes including RRAD (PMID: 36749725), PADI4 (PMID: 37140445), PLTP (PMID: 36309086), PCLO, PLXNB3, and LCN15 with Nutlin treatment and decreased colony suppression in another study (PMID: 32675277), and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 G334R

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Transcript NM_000546.6
gDNA chr17:g.7670709C>T
cDNA c.1000G>A
Protein p.G334R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38
NM_001126112 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670709C>T c.1000G>A p.G334R RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References