Gene Variant Detail

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Gene GNAS
Variant K338R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions GNAS K338R lies within the Ras-like domain of the Gnas protein (PMID: 25802881). K338R has been identified in sequencing studies (PMID: 26168399), but has not been biochemically characterized and therefore, its effect on Gnas protein function is unknown (PubMed, May 2020).
Associated Drug Resistance

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Transcript NM_080425
gDNA chr20:g.58854278A>G
cDNA c.1013A>G
Protein p.K338R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000516 chr20:g.58910376A>G c.1013A>G p.K338R RefSeq GRCh38/hg38
NM_080425 chr20:g.58854278A>G c.1013A>G p.K338R RefSeq GRCh38/hg38
XM_017027812 chr20:g.58854278A>G c.1013A>G p.K338R RefSeq GRCh38/hg38
XM_017027813 chr20:g.58854278A>G c.1013A>G p.K338R RefSeq GRCh38/hg38
XM_017027814 chr20:g.58854278A>G c.1013A>G p.K338R RefSeq GRCh38/hg38

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
GNAS K338R unknown