Gene Variant Detail

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Gene MAP2K1
Variant I111P
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions MAP2K1 I111P lies within the protein kinase domain of the Map2k1 protein (UniProt.org). I111P is predicted to confer a gain of function to the Map2k1 protein as demonstrated by increased basal Map2k1 kinase activity in an in vitro assay and is also associated with resistance to Mek inhibition (PMID: 12370306).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 I111P

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Transcript NM_002755.3
gDNA chr15:g.66436785_66436786delATinsCC
cDNA c.331_332delATinsCC
Protein p.I111P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411 chr15:g.66436785_66436786delATinsCC c.331_332delATinsCC p.I111P RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436785_66436786delATinsCC c.331_332delATinsCC p.I111P RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436785_66436786delATinsCC c.331_332delATinsCC p.I111P RefSeq GRCh38/hg38
NM_002755 chr15:g.66436785_66436786delATinsCC c.331_332delATinsCC p.I111P RefSeq GRCh38/hg38

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 I111P Advanced Solid Tumor predicted - resistant CI-1040 Preclinical - Biochemical Actionable In a preclinical study, CI-1040 (PD184352) did not inhibit kinase activity of MAP2K1 I111P in an in vitro assay (PMID: 12370306). 12370306