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|Variant||ETV6 - SYK|
|Protein Effect||gain of function|
|Gene Variant Descriptions||ETV6-SYK results from the fusion of ETV6 and SYK (PMID: 22373549). ETV6-SYK has been identified in acute lymphoblastic leukemia (PMID: 22373549), and results in constitutive activation of the fusion protein, and is transforming in cultured cells (PMID: 11159536).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ETV6 - SYK||Advanced Solid Tumor||sensitive||HMPL-523||Preclinical - Cell culture||Actionable||In a preclinical study, HMPL-523 decreased viability of cells expressing ETV6-SYK in culture (Blood Dec 2016, 128 (22) 3970).||detail...|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ETV6 - SYK||gain of function|