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|Gene Variant Descriptions||RAD21 T390A lies within the STAG1, WAPL, and PDS5B-interacting regions of the Rad21 protein (UniProt.org). T390A has been demonstrated to have reduced binding to Stag1 and Stag2, when in combination with other Rad21 mutations, L385A, F389A (PMID: 23874961), but has not been individually characterized and therefore, the effect on Rad21 protein function is unknown (PubMed, Mar 2020).|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|