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Gene CDK12
Variant S863L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDK12 S863L lies within the protein kinase domain of the Cdk12 protein (UniProt.org). S863L has been identified in sequencing studies (PMID: 26787835), but has not been biochemically characterized and therefore, its effect on Cdk12 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 S863L

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Transcript NM_016507.4
gDNA chr17:g.39501417_39501418delTCinsCT
cDNA c.2587_2588delTCinsCT
Protein p.S863L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017024749 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524897 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524906 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524902 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_005257458 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
NM_015083 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024744 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024748 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024746 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524903 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524895 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524894 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
NM_016507 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524896 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524899 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024751 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024747 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024745 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524893 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524900 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024750 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524898 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524907 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524901 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524905 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524892 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_017024752 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39501417_39501418delTCinsCT c.2587_2588delTCinsCT p.S863L RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References