Gene Variant Detail

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Gene FGFR3
Variant K650E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR3 K650E (also referred to as K652E from the FGFR3IIIb isoform) lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). K650E confers a gain of function to the Fgfr3 protein as demonstrated by constitutive activation (PMID: 11055896), a growth advantage in a competition assay (PMID: 34272467), and transformation of cells in culture (PMID: 11157491, PMID: 34272467).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 act mut FGFR3 K650E

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Transcript NM_000142.5
gDNA chr4:g.1806162A>G
cDNA c.1948A>G
Protein p.K650E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000142.5 chr4:g.1806162A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_006713873 chr4:g.1806162A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
NM_001354810.2 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_011513422 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
NM_000142 chr4:g.1806162A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1806162A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806162A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806162A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_006713872 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1806162A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.1806159A>G c.1948A>G p.K650E RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806162A>G c.1948A>G p.K650E RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 K650E FGFR3 over exp HRAS K117E myeloid neoplasm sensitive AZ8010 Preclinical Actionable In a preclinical study, AZ8010 inhibited Fgfr3 signaling and decreased proliferation of myeloma cells with HRAS K117E and overexpression of FGFR3 K650E in culture (PMID: 22869148). 22869148
FGFR3 K650E FGFR3 over exp HRAS K117E multiple myeloma sensitive PD173074 Preclinical - Cell culture Actionable In a preclinical study, PD173074 inhibited Fgfr3 signaling, induced cell cycle arrest, and decreased proliferation of multiple myeloma cells harboring HRAS K117E and overexpression of FGFR3 K650E in culture (PMID: 22869148). 22869148
FGFR3 rearrange FGFR3 K650E multiple myeloma predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, Lytgobi (futibatinib) treatment led to inhibition of cell proliferation in a multiple myeloma cell line harboring an FGFR3 rearrangement and FGFR3 K650E in culture (PMID: 32973082). 32973082