Gene Variant Detail

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Gene STAG2
Variant R654I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions STAG2 R654I does not lie within any known functional domains of the Stag2 protein (UniProt.org). R654I has not been characterized and therefore, its effect on Stag2 protein function is unknown (PubMed, Mar 2020).
Associated Drug Resistance

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Transcript NM_001282418
gDNA chrX:g.124063987G>T
cDNA c.1961G>T
Protein p.R654I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011531253 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_005262360 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_005262358 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_017029232 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_005262357 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
NM_001042751 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_005262359 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
NM_006603 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
NM_001042750 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
NM_001042749 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_006724727 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_005262361 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_017029233 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
NM_001282418 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38
XM_017029234 chrX:g.124063987G>T c.1961G>T p.R654I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
STAG2 mutant myelodysplastic syndrome not applicable N/A Guideline Prognostic STAG2 mutations are associated with a poor prognosis in patients with myelodysplastic syndrome (NCCN.org). detail...
Molecular Profile Protein Effect Treatment Approaches
STAG2 R654I unknown