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|Protein Effect||no effect|
|Gene Variant Descriptions||Wild-type RAD21 indicates that no mutation has been detected within the RAD21 gene.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RAD21 wild-type||breast cancer||not applicable||N/A||Preclinical||Emerging||In a preclinical study, siRNA inhibition of RAD21 in breast cancer cells resulted in increased sensitivity to Toposaur (etoposide) in culture, suggesting RAD21 may be a potential therapeutic target for enhanced sensitivity to chemotherapeutics (PMID: 15767545).||15767545|
|Molecular Profile||Protein Effect||Treatment Approaches|
|RAD21 wild-type||no effect|