Gene Variant Detail

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Gene ERBB2
Variant G776_V777insVC
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions ERBB2 (HER2) G776_V777insVC results in the insertion of two amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 776 and 777 (UniProt.org). G776_V777insVC has not been biochemically characterized, however, other Erbb2 (Her2) exon 20 insertions are activating (PMID: 16843263, PMID: 17311002, PMID: 23220880), and therefore, G776_V777insVC is predicted to lead to gain of Erbb2 (Her2) function.
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39724748_39724749insATGTGT
cDNA c.2330_2331insATGTGT
Protein p.V777_G778insCV
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004448 chr17:g.39724748_39724749insATGTGT c.2330_2331insATGTGT p.V777_G778insCV RefSeq GRCh38/hg38
NM_001289937 chr17:g.39724748_39724749insATGTGT c.2330_2331insATGTGT p.V777_G778insCV RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Protein Effect Treatment Approaches
ERBB2 G776_V777insVC gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References