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|Variant||ETV6 - LYN|
|Protein Effect||gain of function|
|Gene Variant Descriptions||ETV6-LYN results from the fusion of ETV6 and LYN, demonstrating constitutive Lyn kinase activity and the ability to phosphorylate Stat5, and is transforming in cell culture (PMID: 21492125).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ETV6 - LYN||gain of function|