Gene Variant Detail

Gene AKT1
Variant W80R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions AKT1 W80R lies within the PH domain of the Akt1 protein (UniProt.org). W80R results in increased repression of FOXO3a compared to wild-type Akt1 in an in vitro assay (PMID: 26137586), and therefore is predicted to result in a gain of Akt1 protein function.
Associated Drug Resistance

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Transcript NM_001014432
gDNA chr14:g.104776708A>T
cDNA c.238T>A
Protein p.W80R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001014431 chr14:g.104776708A>T c.238T>A p.W80R RefSeq GRCh38/hg38
XM_017021077 chr14:g.104776708A>T c.238T>A p.W80R RefSeq GRCh38/hg38
NM_005163 chr14:g.104776708A>T c.238T>A p.W80R RefSeq GRCh38/hg38
XM_017021075 chr14:g.104776708A>T c.238T>A p.W80R RefSeq GRCh38/hg38
XM_005267401 chr14:g.104776708A>T c.238T>A p.W80R RefSeq GRCh38/hg38
XM_017021078 chr14:g.104776708A>T c.238T>A p.W80R RefSeq GRCh38/hg38
XM_017021076 chr14:g.104776708A>T c.238T>A p.W80R RefSeq GRCh38/hg38
NM_001014432 chr14:g.104776708A>T c.238T>A p.W80R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
AKT1 W80R gain of function - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References