Gene Variant Detail

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Gene PIK3CA
Variant P449_L455del
Impact List deletion
Protein Effect gain of function
Gene Variant Descriptions PIK3CA P449_L455del results in the deletion of seven amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 449 to 455 (UniProt.org). P449_L455del results in increased Akt phosphorylation in cell culture relative to wild-type Pik3ca in culture (PMID: 21266528) and demonstrates increased transformation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785).
Associated Drug Resistance

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Transcript NM_006218
gDNA chr3:g.179210280_179210300del21
cDNA c.1346_1366del21
Protein p.P449_L455delPHGLEDL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658 chr3:g.179210280_179210300del21 c.1346_1366del21 p.P449_L455delPHGLEDL RefSeq GRCh38/hg38
NM_006218 chr3:g.179210280_179210300del21 c.1346_1366del21 p.P449_L455delPHGLEDL RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210280_179210300del21 c.1346_1366del21 p.P449_L455delPHGLEDL RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References