Gene Variant Detail

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Gene PIK3CA
Variant R38H
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA R38H lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R38H results in moderate increase of Pik3ca kinase activity and Akt phosphorylation, but is not transforming in cell culture (PMID: 15930273), however in another study, R38H increased transformation in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785).
Associated Drug Resistance

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Transcript NM_006218
gDNA chr3:g.179198938G>A
cDNA c.113G>A
Protein p.R38H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179198938G>A c.113G>A p.R38H RefSeq GRCh38/hg38
XM_006713658 chr3:g.179198938G>A c.113G>A p.R38H RefSeq GRCh38/hg38
XM_011512894 chr3:g.179198938G>A c.113G>A p.R38H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References