Gene Variant Detail

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Gene CDK12
Variant K756R
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions CDK12 K756R lies within the protein kinase domain of the Cdk12 protein (UniProt.org). K756R results in a kinase dead Cdk12 protein (PMID: 24554720).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 K756R

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Transcript NM_016507.4
gDNA chr17:g.39494542A>G
cDNA c.2267A>G
Protein p.K756R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436266.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436290.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436263.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436280.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524899 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524901 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524898 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524897 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024746 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436253.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436291.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524894 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436285.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524907 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436283.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024745 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524906 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436284.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_005257456.4 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
NM_015083 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524892 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436262.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_005257458 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524896 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024749 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524902 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024751 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436264.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524905 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_005257456 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024752 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524895 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024753 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024744 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436281.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024750 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436286.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524893 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024753.3 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024753.2 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524900 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024747 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436282.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024748 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436292.1 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_005257456.5 chr17:g.39494545A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
NM_016507 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524903 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39494542A>G c.2267A>G p.K756R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References