Gene Variant Detail

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Gene ERBB2
Variant Y835F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ERBB2 (HER2) Y835F lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). Y835F results in decreased Erbb2 (Her2) kinase activity, reduced cell proliferation, and is not transforming in culture in one study (PMID: 23220880), and in another study, results in similar cell proliferation and viability levels to wild-type Erbb2 (Her2) in two different cell lines (PMID: 29533785), and therefore its effect on Erbb2 (Her2) protein function is unknown.
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39725059A>T
cDNA c.2504A>T
Protein p.Y835F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001289937 chr17:g.39725059A>T c.2504A>T p.Y835F RefSeq GRCh38/hg38
NM_004448 chr17:g.39725059A>T c.2504A>T p.Y835F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ERBB2 Y835F unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References