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Gene PALB2
Variant E645K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PALB2 E645K does not lie within any known functional domains of the Palb2 protein (UniProt.org). E645K has not been characterized in the scientific literature and therefore, its effect on Palb2 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

PALB2 mutant PALB2 E645K

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Transcript NM_024675.4
gDNA chr16:g.23630221C>T
cDNA c.1933G>A
Protein p.E645K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011545948 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
XM_017023672.2 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407306.1 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407299.1 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407310.1 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407304.1 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407302.1 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_024675.3 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
XM_017023672 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407311.1 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407301.1 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_024675.4 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407298.1 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
XM_017023673.2 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407297.1 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_024675 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
XM_017023673 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
XM_011545948.2 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407300.1 chr16:g.23630221C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407309.1 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407305.1 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38
NM_001407308.1 chr16:g.23624025C>T c.1933G>A p.E645K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References