Gene Variant Detail

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Gene TP53
Variant E171_V172insDDV
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions TP53 E171_V172insDDV results in the insertion of three amino acids in the DNA-binding domain of the Tp53 protein between amino acids 171 and 172 (PMID: 22713868). E171_V172insDDV has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 E171_V172insDDV

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Transcript NM_000546.6
gDNA chr17:g.7675098_7675099insTACGTCGTC
cDNA c.514_515insACGACGTAG
Protein p.E171_V172insDDV
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675098_7675099insTACGTCGTC c.514_515insACGACGTAG p.E171_V172insDDV RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References