Gene Variant Detail

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Gene TP53
Variant G245_M246insAMC
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions TP53 G245_M246insAMC results in the insertion of three amino acids in the DNA-binding domain of the Tp53 protein between amino acids 245 and 246 (PMID: 22713868). G245_M246insAMC has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 G245_M246insAMC

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Transcript NM_000546.6
gDNA chr17:g.7674227_7674228insACACATTGC
cDNA c.735_736insGCAATGTGT
Protein p.G245_M246insAMC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407270.1 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_000546 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674227_7674228insACACATTGC c.735_736insGCAATGTGT p.G245_M246insAMC RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References