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Gene FGFR2
Variant S252F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 S252F lies within the extracellular domain of the Fgfr2 protein (UniProt.org). S252F has been identified in sequencing studies (PMID: 16418739), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 S252F

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Transcript NM_000141.5
gDNA chr10:g.121520162_121520163delCGinsTT
cDNA c.755_756delCGinsTT
Protein p.S252F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.3 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520162_121520163delCGinsAA c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_000141 chr10:g.121520162_121520163delCGinsAA c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520162_121520163delCGinsAA c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520162_121520163delCGinsAA c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_022970 chr10:g.121520162_121520163delCGinsAA c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520162_121520163delCGinsTT c.755_756delCGinsTT p.S252F RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References