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Gene | TET2 |
Variant | P1889H |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TET2 P1889H lies within the catalytic domain of the Tet2 protein (PMID: 28242787). P1889H has been identified in sequencing studies (PMID: 21828143), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Sep 2020). |
Associated Drug Resistance |
Transcript | NM_001127208.2 |
gDNA | chr4:g.105276176C>A |
cDNA | c.5666C>A |
Protein | p.P1889H |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001127208 | chr4:g.105276176C>A | c.5666C>A | p.P1889H | RefSeq | GRCh38/hg38 |
NM_001127208.2 | chr4:g.105276176C>A | c.5666C>A | p.P1889H | RefSeq | GRCh38/hg38 |
XM_024454103.1 | chr4:g.105276176C>A | c.5666C>A | p.P1889H | RefSeq | GRCh38/hg38 |
XM_005263082.3 | chr4:g.105276176C>A | c.5666C>A | p.P1889H | RefSeq | GRCh38/hg38 |
XM_024454102.1 | chr4:g.105276176C>A | c.5666C>A | p.P1889H | RefSeq | GRCh38/hg38 |
XM_005263082 | chr4:g.105276176C>A | c.5666C>A | p.P1889H | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
TET2 P1889H | unknown |