Gene Variant Detail

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Gene SRC
Variant T341I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions SRC T341I lies within the protein kinase domain of the Src protein (UniProt.org). T341I results in increased Src autophosphorylation, substrate phosphorylation, and cell survival in culture (PMID: 18794843, PMID: 29930727) and demonstrates resistance to Src inhibition in cell culture (PMID: 29930727, PMID: 19098899).
Associated Drug Resistance Y

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Transcript NM_198291
gDNA chr20:g.37400277_37400278delCGinsTC
cDNA c.1022_1023delCGinsTC
Protein p.T341I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011529013 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
NM_005417 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38
NM_198291 chr20:g.37400277_37400278delCGinsTC c.1022_1023delCGinsTC p.T341I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
SRC T341I gain of function Bosutinib
IDH1 R132C SRC T341I
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132C SRC T341I intrahepatic cholangiocarcinoma resistant Dasatinib Preclinical - Cell culture Actionable In a preclinical study, intrahepatic cholangiocarcinoma cells harboring IDH1 R132S acquired resistance to Sprycel (dasatinib) after over expressing SRC T341I in culture (PMID: 27231123). 27231123