Gene Variant Detail

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Gene DNMT3A
Variant G746V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A G746V lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). G746V has been identified in the scientific literature (PMID: 27147599), but has not been biochemically characterized and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Oct 2018).
Associated Drug Resistance

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Transcript NM_022552
gDNA chr2:g.25240387C>A
cDNA c.2237G>T
Protein p.G746V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_175629 chr2:g.25240387C>A c.2237G>T p.G746V RefSeq GRCh38/hg38
XM_005264175 chr2:g.25240387C>A c.2237G>T p.G746V RefSeq GRCh38/hg38
XM_011532664 chr2:g.25240387C>A c.2237G>T p.G746V RefSeq GRCh38/hg38
NM_022552 chr2:g.25240387C>A c.2237G>T p.G746V RefSeq GRCh38/hg38
XM_017003526 chr2:g.25240387C>A c.2237G>T p.G746V RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
DNMT3A G746V unknown