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Gene KEAP1
Variant S580R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KEAP1 S580R lies within Kelch repeat 6 of the Keap1 protein (UniProt.org). S580R has not been characterized in the scientific literature and therefore, its effect on Keap1 protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance
Category Variants Paths

KEAP1 mutant KEAP1 S580R

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Transcript NM_203500.2
gDNA chr19:g.10486787A>C
cDNA c.1740T>G
Protein p.S580R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_012289 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
XM_011528452.1 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
XM_005260173.1 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
XM_011528452 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
XM_005260174.1 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
NM_012289.3 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
XM_005260173 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
NM_203500 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
NM_203500.1 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
NM_012289.4 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
XM_005260174 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38
NM_203500.2 chr19:g.10486787A>C c.1740T>G p.S580R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References