Gene Variant Detail

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Gene ROS1
Variant S32I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 S32I lies within the extracellular domain of the Ros1 protein (UniProt.org). S32I has been identified in sequencing studies (PMID: 26960398), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2022).
Associated Drug Resistance

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Transcript NM_002944.2
gDNA chr6:g.117425562C>A
cDNA c.95G>T
Protein p.S32I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017011172 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536054.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536049.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536057 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_006715548 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536055 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536049 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_017011173 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536052 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536053 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536058.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_006715548.4 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
NM_002944 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536056.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536051 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536052.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536054 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536050.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536058 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536056 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536053.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536057.3 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536050 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536055.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117425562C>A c.95G>T p.S32I RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ROS1 S32I unknown