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|Variant||FGFR2 - CCAR2|
|Gene Variant Descriptions||FGFR2-CCAR2 (also referred to as FGFR2-KIAA1967) results from the fusion of FGFR2 and CCAR2 (PMID: 23558953). FGFR2-CCAR2 has been identified in lung cancer (PMID: 27245147, PMID: 23558953), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, May 2020).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 - CCAR2||intrahepatic cholangiocarcinoma||predicted - sensitive||Derazantinib||Case Reports/Case Series||Actionable||In a Phase Ib/II trial, a patient with intrahepatic cholangiocarcinoma harboring FGFR2-CCAR2 demonstrated stable disease when treated with Derazantinib (ARQ 087) (PMID: 30420614; NCT01752920).||30420614|
|Molecular Profile||Protein Effect||Treatment Approaches|
|FGFR2 - CCAR2||unknown|