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|Variant||FGFR2 - FAM76A|
|Protein Effect||gain of function - predicted|
|Gene Variant Descriptions||FGFR2-FAM76A results from the fusion of FGFR2 and FAM76A, which leads to increased proliferation and transformation in cell culture (PMID: 24563622) and therefore, is predicted to result in a gain of protein function. FGFR2-FAM76A has been identified in ovarian cancer (PMID: 24563622).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 - FAM76A||ovarian cancer||sensitive||Infigratinib||Preclinical - Patient cell culture||Actionable||In a preclincal study, Infigratinib (BGJ398) demonstrated enhanced inhibition of the survival in patient-derived ovarian cancer cells harboring FGFR2 - FAM76A in culture (PMID: 24563622).||24563622|